测试ID：MOSP
小鼠血清蛋白，IgE，血清

建立对小鼠血清蛋白过敏的诊断

defining the allergen responsible for eliciting signs and symptoms

识别过敏原：

- 对过敏性疾病和/或过敏性发作负有反应

-To confirm sensitization prior to beginning immunotherapy

-To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens

直接性高敏性（过敏性）疾病的临床表现是由免疫球蛋白E（IgE）敏化效应细胞（MAST和Basophils）相互作用时从免疫球蛋白E（IgE）敏感性抗体细胞中释放促炎性介质（组胺，白细胞和前列腺素）引起的。。

IgE抗体的体外血清测试提供了对过敏原的免疫反应，可能与过敏性疾病有关。

the allergens chosen for testing often depend upon the age of the patient, history of allergen exposure, season of the year, and clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).

参考值适用于所有年龄段。

血清中IgE抗体的检测（1类或更高）表明过敏性疾病的可能性增加，而不是其他病因，并定义了可能导致征兆和症状的过敏原。

the level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

一些对过敏原临床敏感性微不足道的个体可能具有可测量的血清中IgE抗体水平，并且必须在临床背景下解释结果。

由于非特异性与过敏原固体相结合，血清IgE（> 2500 kU/L）的患者可能会出现IgE抗体的假阳性结果。

HOMBURGER HA，HAMILTON RG：第55章：过敏性疾病。在亨利的临床诊断和通过实验室方法中。第23版。由Ra McPherson编辑，Pincus先生。Elsevier，2017年，第1057-1070页

• 过敏原 - 免疫球蛋白E（IgE）抗体